PDE-REPORT-AS-A-SERVICE

Permitted Daily Exposure Limits for any substance.

Why are PDE reports essential?

If different pharmaceutical products are manufactured in shared facilities, there’s always a risk of cross-contamination due to residuals of pharmaceutical ingredients, by-products, or detergents. To reduce the danger for people using your final product, it’s essential to know how many residues of a certain substance could technically still be in the used equipment without causing any harm.

The Permitted Daily Exposure (PDE) marks the dose of a specific substance that’s unlikely to cause an adverse effect if the same person is exposed to this amount – or less – every day, for a lifetime.

Consequently, it is important to know this limit for every substance that could technically be found in your final product, and to make sure it’s at most contained in its daily dose. The PDE can then be used to calculate other necessary limit values, and to determine which equipment – or even facility – should be used dedicated to specific products.

The way we work

Since it is an essential value, the exposure limit is based on calculations determined by the official European Medicine Agency guideline (EMA/CHMP/ CVMP/ SWP/169430/2012). As requested by the guideline, our determination of the PDE involves:

  • Hazard identification by reviewing all relevant data, such as medicinal and toxicological data bases and studies

  • Identification of 'critical effects', i.e. the most harmful effects a substance can have

  • Determination of the no-observed-adverse-effect level (NOAEL) of the findings that are considered to be critical effects

  • Careful use of several modifying factors to account for various uncertainties, such as non-ideal conditions in the consulted studies

    Quality is crucial: Our quality promise

    We provide PDE reports for any active pharmaceutical ingredient (API). A large pool of existing reports is already available to choose from, but we’re more than happy to create a new one to add to the list for an additional API, if necessary.

    Our focus lies on the quality of every single report. So while not all reports may be available for immediate download, we can make sure you get exactly what you need for the situation at hand, and in the best possible quality.

    To ensure this, our quality promise includes:

    • an accomplished, multidisciplinary team, supported by experienced and certified toxicologists
    • compliance with the official EMA guideline
    • PDE reports with a comprehensive structure to make all information easily accessible
    • PDE reports based on the toxicological properties and pharmacology of the specific API

    Route of Administration

    While PDE reports are essential, the route of administration is, in turn, essential for them. Find out more about why that is the case and what's especially important to keep in mind in the video below.

    Full list of available PDE reports

    Substance name

    CAS No.

    Route of exposure

    (+)-Cloprostenol Sodium

    62561-03-9

    Parenteral

    (R)-1-(8-fluoroisochroman-1-yl)-N-methylmethanamine phosphate

    n.a.

    (in development)

    Oral

    5-Fluorouracil

    51-21-8

    Parenteral;

    Cutaneous

    7-Bromo-4-chloro-1-(2,2,2-trifluoroethyl)-1H-indazol-3-amine

    2189684-52-2

    Oral;

    Inhalation

    Abemaciclib

    1231929-97-7

    Oral

    Acarbose

    56180-94-0

    Oral

    Aceclofenac

    89796-99-6

    Oral

    Acenocoumarol

    152-72-7

    Oral

    Acetazolamide

    59-66-5;

    1424-27-7

    Oral

    Acetylcysteine

    928672-86-0

    Oral;

    Parenteral;

    Inhalation

    Acetylsalicylic acid

    50-78-2

    Oral

    Acyclovir

    59277-89-3

    Oral;

    Cutaneous

    Ademetionine

    29908-03-0

    Oral;

    Parenteral

    Agomelatine

    138112-76-2

    Oral

    Alfacalcidol

    41294-56-8

    Oral

    Allopurinol

    315-30-0

    Oral

    Allylestrenol

    432-60-0

    Oral

    Alprazolam

    28981-97-7

    Oral

    Alprostadil

    745-65-3

    Parenteral

    Aluminium potassium sulfate dodecahydrate

    7784-24-9

    Oral

    Aluminum hydroxide

    21645-51-2

    Oral

    Aluminum potassium sulfate dodecahydrate

    7784-24-9

    Oral

    Ambrisentan

    177036-94-1

    Oral

    Ambroxol

    18683-91-5

    Oral;

    Parenteral

    Ambroxol hydrochloride

    23828-92-4

    Oral;

    Parenteral

    Amikacin

    39831-55-5

    Parenteral

    Amiloride

    2609-46-3

    Oral

    Aminopentamide

    60-46-8

    Oral

    Aminophylline anhydrous fine powder

    317-34-0

    Oral

    Amitriptyline

    50-48-6;

    549-18-8

    Oral

    Amlodipine

    88150-42-9

    Oral

    Amlodipine besylate

    111470-99-6

    Oral

    Ammonium chloride

    12125-02-9

    Oral;

    Parenteral

    Amoxicillin

    26787-78-0

    Oral;

    Parenteral

    Ampicillin Trihydrate

    7177-48-2

    Oral;

    Parenteral

    Apixaban

    503612-47-3

    Oral

    Aprocitentan

    1103522-45-7

    Oral

    Arachidonic acid

    506-32-1

    Oral

    Ascorbic acid

    50-81-7

    Oral;

    Parenteral

    Atorvastatin calcium trihydrate

    344423-98-9

    Oral

    Azelaic acid

    123-99-9

    Oral;

    Cutaneous

    Azilsartan

    147403-03-0

    Oral

    Azilsartan kamedoxomil

    863031-24-7

    Oral

    Azithromycin

    83905-01-5

    Oral;

    Parenteral

    Beclomethasone dipropionate

    5534-09-8

    Oral;

    Inhalation

    Benserazide hydrochloride

    14919-77-8

    Oral;

    Inhalation

    Beraprost

    88475-69-8

    Oral

    Betahistine mesilate

    54856-23-4;

    5579-84-0

    Oral

    Betamethasone

    378-44-9

    Oral;

    Cutaneous

    Betamethasone (Betamethasone salts)

    378-44-9;

    987-24-6;

    5593-20-4;

    2152-44-5;

    22298-29-9;

    360-63-4;

    151-73-5

    Oral;

    Parenteral;

    Cutaneous

    Bimatoprost

    155206-00-1

    Ocular

    Biotin

    58-85-5

    Oral;

    Parenteral

    Bisacodyl

    603-50-9

    Oral;

    Cutaneous;

    Rectal

    Bisoprolol fumarate

    104344-23-2;

    66722-44-9

    Oral

    Black Elderberry dry ext.

    7084-24-4

    Oral

    Brinzolamide

    138890-62-7

    Ocular

    Bromazepam

    1812-30-2

    Oral

    Bromfenac Sodium Sesquihydrate

    120638-55-3

    Ocular

    Bromhexine hydrochloride

    611-75-6

    Oral

    Budesonide

    51333-22-3

    Oral;

    Inhalation

    Bupivacaine HCL

    73360-54-0

    Parenteral

    Butylphthalide

    6066-49-5

    Oral

    Cabergoline

    81409-90-7

    Oral

    Caesium chloride

    7647-17-8

    Parenteral

    Caffeine

    58-08-2

    Oral

    Caffeine anhydrous

    58-08-2

    Oral

    Calcium carbonate

    471-34-1

    Oral;

    Cutaneous

    Calcium chloride & its hydrated forms

    10043-52-4;

    10035-04-8;

    7774-34-7

    Parenteral;

    Cutaneous

    Calcium folinate

    1492-18-8

    Oral

    Calcium hypophosphite

    7789-79-9

    Oral;

    Parenteral

    Calcium lactate

    5743-48-6

    Oral

    Calcium pantothenate

    137-08-6

    Oral;

    Ocular

    Camphor

    76-22-2

    Cutaneous;

    Inhalation

    Canagliflozin hemihydrate

    928672-86-0

    Oral

    Candesartan ciletexil

    145040-37-5

    Oral

    Cannabidiol

    13956-29-1

    Oral;

    Inhalation

    Captopril

    62571-86-2

    Oral

    Carbamazepine

    298-46-4

    Oral

    Carboplatin

    41575-94-4

    Parenteral

    Carvedilol

    72956-09-3

    Oral

    Cefaclor

    53994-73-3

    Oral

    Cefadroxil

    66592-87-8

    Oral

    Cefamandole nafate

    42540-40-9

    Parenteral

    Cefazoline

    25953-19-9

    Parenteral

    Cefdinir

    91832-40-5

    Oral

    Cefepime

    88040-23-7

    Parenteral

    Cefixime

    79350-37-1

    Oral

    Cefoperazone

    113826-44-1

    Parenteral

    Cefoperazone sodium

    62893-20-3

    Oral;

    Parenteral

    Cefotaxime

    63527-52-6

    Parenteral

    Cefotaxime sodium

    6485-93-4

    Parenteral

    Cefotiam hydrochloride

    66309-69-1

    Parenteral

    Cefoxitin Na

    33564-30-6

    Parenteral

    Cefpirome sulfate

    98753-19-6

    Oral

    Ceftazidime

    72558-82-8

    Parenteral

    Ceftazidime sodium

    73547-61-2

    Parenteral

    Ceftizoxime sodium

    68401-82-1

    Parenteral

    Ceftriaxone sodium

    104376-79-6

    Parenteral

    Cefuroxime

    55268-75-2

    Oral

    Cefuroxime axetil

    64544-07-6

    Oral

    Cefuroxime sodium

    56238-63-2

    Oral

    Celecoxib

    169590-42-5

    Oral

    Cephalexin

    15686-71-2

    Oral

    Cetirizine hydrochloride (and free base)

    83881-52-1;

    83881-51-0

    Oral

    Cetrimonium bromide

    57-09-0

    Oral

    Chloramphenicol Sodium

    56-75-7;

    982-57-0;

    530-43-8

    Oral;

    Ocular;

    Parenteral

    Chlordiazepoxide HCl

    58-25-3

    Oral

    Chlorhexidine

    55-56-1

    Cutaneous

    Chlorhexidine (di)gluconate

    18472-51-0

    Oral;

    Cutaneous

    Chlorpheniramine maleate

    113-92-8

    Oral

    Choline

    62-49-7

    Oral

    Chondroitin Sulfate Sodium

    9007-28-7

    Oral

    Ciclesonide

    126544-47-6

    Inhalation

    Cilastatin sodium

    82009-34-5

    Parenteral

    Ciprofloxacin HCL monohydrate

    86393-32-0

    Oral;

    Parenteral

    Cisatracurium besylate

    96946-42-8

    Parenteral

    Citalopram

    59729-32-8

    Oral

    Citicoline

    987-78-0

    Parenteral

    Clarithromycin

    81103-11-9

    Oral

    Clavulanic acid

    58001-44-8

    Oral;

    Parenteral

    Clindamycin HCl

    21462-39-5

    Oral;

    Parenteral;

    Cutaneous

    Clinidium bromide

    7020-55-5

    Oral

    Clioquinol

    130-26-7

    Oral;

    Cutaneous

    Clobetasol propionate

    25122-41-2

    Oral;

    Cutaneous

    Clonazepam

    1622-61-3

    Oral

    Clopidogrel besilate

    744256-69-7

    Oral

    Clopidogrel bisulfate

    120202-66-6

    Oral

    Clotrimazole

    23593-75-1

    Cutaneous

    Codeine

    76-57-3

    Oral

    Coenzyme Q10

    303-98-0

    Oral

    Colestipol hydrochloride

    4961-41-5

    Oral

    Copper gluconate

    527-09-3

    Oral

    Copper II chloride, dihydrate

    10125-13-0

    Parenteral

    Crisaborole

    906673-24-3

    Oral

    Curcuma xanthoriza

    458-37-7;

    30199-26-9

    Oral

    Cyanocobalamin / Vitamin B12

    68-19-9

    Oral;

    Parenteral

    Cyproheptadine

    129-03-3

    Oral

    Cyproterone acetate

    427-51-0

    Oral

    D,L-Alpha-Tocopherol acetate (Vit. E acetate)

    52225-20-4

    Oral;

    Parenteral

    Dabigatran Etexilate Mesylate

    872728-81-9

    Oral

    Dapagliflozin propylene glycolate hydrate

    960404-48-2

    Oral

    Dasatinib

    302962-49-8

    All routes

    Delta9-Tetrahydrocannabinolic acid (THC)

    1972-08-3

    Oral;

    Inhalation

    Desloratadine

    100643-71-8

    Oral

    Desoximetasone

    382-67-2

    Cutaneous

    Dexamethasone

    50-02-2

    Oral;

    Parenteral;

    Cutaneous;

    Ocular;

    Otic

    Dexamethasone acetate (and sodium phosphate)

    50-02-2;

    2392-39-4

    Oral;

    Parenteral;

    Cutaneous;

    Ocular;

    Otic

    Dexketoprofen Trometamol

    156604-79-4

    Parenteral

    Dexpanthenol

    81-13-0

    Oral;

    Cutaneous;

    Inhalation;

    Ocular

    Dextran-70

    9004-54-0

    Ocular

    Dextromethorphan HBr

    125-71-3;

    125-69-9;

    6700-34-1

    Oral

    Dextrose

    50-99-7;

    2280-44-6

    Parenteral

    DHA

    6217-54-5

    Oral;

    Parenteral

    Diazepam

    439-14-5

    Oral;

    Parenteral;

    Rectal

    Dibutyl phthalate

    84-74-2

    Parenteral

    Diclofenac and salts (potassium, diethylammonium)

    15307-86-5;

    78213-16-8;

    15307-81-0

    Oral;

    Parenteral;

    Cutaneous

    Diclofenac diethylamine

    78213-16-8

    Cutaneous

    Diclofenac epolamine

    119623-66-4

    Cutaneous

    Diclofenac sodium

    15307-79-6

    Ocular;

    Oral;

    Parenteral;

    Cutaneous

    Diethanolamine

    111-42-2

    Parenteral

    Dinoprost (tromethamine)

    38562-01-5

    Oral;

    Parenteral

    Dinoprostone

    363-24-6

    Vaginal

    Diphenhydramine HCl

    147-24-0

    Oral;

    Parenteral

    Docetaxel

    114977-28-5

    Parenteral

    Domperidone Maleate

    83898-65-1

    Oral

    Donepezil HCl

    120011-70-3

    Oral

    Doripenem

    148016-81-3

    Oral

    Doxorubicin HCL

    25136-40-9

    Parenteral

    Doxycycline hyclate

    24390-14-5

    Oral

    Doxylamine succinate

    562-10-7

    Oral

    Duloxetine

    116539-59-4

    Oral

    Dydrogesterone

    152-62-5

    Oral

    Echinacea purpurea

    84696-11-7

    Oral;

    Parenteral

    Econazole nitrate

    24169-02-6

    Cutaneous

    Edoxaban tosylate monohydrate

    1229194-11-9

    Oral

    Epigallocatechin Gallate (EGCG)

    989-51-5

    Oral

    Eldecalcitol

    104121-92-8

    Oral

    Empagliflozin

    864070-44-0

    Oral

    Entecavir Monohydrate

    209216-23-9

    Oral

    Ephedrine sulphate

    134-72-5

    Oral

    Epirubicin HCl

    56390-09-1

    Parenteral;

    Intravesicular

    Epoprostenol sodium

    61849-14-7

    Parenteral

    Ergocalciferol (vit. D2)

    50-14-6

    Oral

    Erythromycin

    114-07-8

    Oral;

    Parenteral;

    Cutaneous

    Escitalopram

    219861-08-2

    Oral

    Esomeprazole

    119141-88-7

    Oral;

    Parenteral

    Esomeprazole sodium

    161796-78-7

    Oral;

    Parenteral

    Estradiol

    50-28-2

    Oral;

    Cutaneous

    Estradiol Valerate

    979-32-8

    Oral

    Ethinylestradiol

    57-63-6

    Oral

    Etoricoxib

    202409-33-4

    Oral;

    Parenteral

    Eucalyptus oil

    8000-48-4

    Oral;

    Cutaneous;

    Inhalation

    Eugenol

    97-53-0

    Oral;

    Cutaneous;

    Buccal

    Evocalcet

    870964-67-3

    Oral

    Febuxostat

    144060-53-7

    Oral

    Fenofibrate

    256-376-3

    Oral

    Ferrous fumarate

    141-01-5

    Oral

    Ferrous gluconate

    299-29-6

    Oral

    Filgrastim

    121181-53

    Parenteral

    Finasteride

    98319-26-7

    Oral

    Fluconazole

    86386-73-4

    Oral

    Fludrocortisone Acetate

    514-36-3

    Ocular

    Fluocinolone acetonide

    67-73-2

    Cutaneous

    Fluorometholone

    426-13-1

    Ocular

    Fluticasone propionate

    80474-14-2

    Cutaneous

    Folic acid

    59-30-3

    Oral;

    Parenteral

    Fosfomycin

    23155-02-4

    Oral

    Fructose

    57-48-7

    Parenteral

    Furosemide

    54-31-9

    Parenteral

    Gabapentin

    60142-96-3

    Oral

    Galactooligosaccharide

    6587-31-1

    Oral

    Gelatin

    9000-70-8

    Oral

    Gemcitabine

    95058-81-4

    Parenteral

    Gemfibrozil

    25812-30-0

    Oral

    Gentamicin sulfate

    1405-41-0

    Parenteral;

    Cutaneous;

    Ocular

    Gliclazide

    21187-98-4

    Oral

    Glimepiride

    93479-97-1

    Oral

    Glucosamine

    3416-24-8

    Oral

    Glucose

    50-99-7

    Oral;

    Parenteral;

    Buccal

    Glycin

    56-40-6

    Oral;

    Parenteral

    Glycopyrrolate

    596-51-0

    Parenteral

    Guaifenesin

    93-14-1

    Oral

    Haloperidol

    52-86-8

    Oral

    Heparin sodium

    9041-08-1

    Parenteral;

    Cutaneous;

    Ocular

    Hydrochlorothiazide

    58-93-5

    Oral

    Hydrocodone

    125-29-1

    Oral

    Hydrocortisone

    50-23-7

    Oral;

    Parenteral;

    Cutaneous

    Hydroxychloroquine

    747-36-4

    Oral

    Hydroxyethyl starch

    9005-27-0

    Oral;

    Parenteral;

    Inhalation

    Ibuprofen

    15687-27-1

    Oral

    Iloprost

    78919-13-8

    Parenteral;

    Inhalation

    Imipenem (anhydrous)

    64221-86-9

    Parenteral

    Imipenem monohydrate

    74431-23-5

    Parenteral

    Indapamide

    26807-65-8

    Oral;

    Parenteral

    Infliximab

    170277-31-3

    Parenteral

    Inositol

    87-89-8

    Oral;

    Cutaneous

    Insulin aspart

    116094-23-6

    Parenteral

    Insulin Glargine

    160337-95-1

    Parenteral

    Ipragliflozin

    960404-48-2

    Oral

    Ipragliflozin L-Proline

    951382-34-6

    Oral

    Irinotecan

    97682-44-5

    Parenteral

    Iron polymaltose complex

    53858-86-9

    Oral

    Isosorbide dinitrate

    87-33-2

    Parenteral

    Isosorbide mononitrate

    16051-77-7

    Oral

    Isradipine

    75695-93-1

    Oral;

    Inhalation

    Itopride hydrochloride

    122898-67-3

    Oral

    Kaolin

    1332-58-7

    Oral

    Ketoconazole

    65277-42-1

    Oral;

    Cutaneous;

    Vaginal

    Ketoprofen

    22071-15-4

    Oral;

    Parenteral

    Ketorolac tromethamine

    74103-07-4

    Oral;

    Parenteral

    Ketotifen Hydrogen Fumarate

    34580-14-8

    Oral

    L-Alanyl-L-Glutamine

    39537-23-0

    Parenteral

    L-asparagine monohydrate

    5794-13-8;

    70-47-3

    Parenteral

    L-Tyrosine

    60-18-4

    Parenteral

    Lansoprazole

    103577-45-3

    Oral;

    Parenteral

    Latanoprost

    130209-82-4

    Ocular

    Latanoprostene bunod

    860005-21-6

    Ocular

    Levamlodipine Besylate

    150566-71-5

    Oral

    Levetiracetam

    102767-28-2

    Oral

    Levobupivacaine hydrochloride

    27262-47-1

    Parenteral

    Levofloxacin hemihydrate

    100986-85-4

    Oral;

    Parenteral

    Levomenthol synthetic

    2216-51-5

    Cutaneous;

    Inhalation

    Levonorgestrel

    797-63-7

    Oral

    Levosimendan

    141505-33-1

    Oral

    Lidocaine

    137-58-6

    Cutaneous

    Lidocaine hydrochloride

    73-78-9

    Ocular;

    Oral;

    Parenteral;

    Cutaneous

    Lifitegrast

    1025967-78-5

    Ocular

    Limaprost

    74397-12-9

    Oral

    Limaprost Alfadex

    88852-12-4

    Oral

    Linezolid

    165800-03-3

    Oral

    Liquitirae radix

    977004-31-1

    Oral

    Lisinopril

    76547-98-3

    Oral

    Loperamide

    53179-11-6

    Oral

    Loperamide HCL

    34552-83-5

    Oral

    Loratadine

    79794-75-5

    Oral

    Losartan Potassium

    124750-99-8

    Oral

    Lovastatin

    75330-75-5

    Oral

    Lubiprostone

    136790-76-6

    Oral

    Lycopene

    502-65-8

    Oral

    Lysine

    56-87-1

    Oral;

    Parenteral

    Lysine- HCl

    56-87-1

    Oral

    Magnesium Acetate Tetrahydrate

    16674-78-5

    Parenteral

    Magnesium adipate

    7486-39-7

    Parenteral

    Magnesium Chloride Hexahydrate

    7786-30-3;

    7487-88-9

    Oral;

    Parenteral

    Magnesium hydroxide

    1309-42-8

    Oral

    Magnesium oxide

    1309-48-4

    Oral

    Magnesium Trisilicate (Light)

    14987-04-3

    Oral

    Maltose

    69-79-4

    Oral;

    Parenteral

    Manganese sulfate

    10034-96-5

    Oral

    Mannitol

    69-65-8;

    87-78-5

    Oral;

    Parenteral;

    Inhalation

    Marbofloxacin

    115550-35-1

    Oral

    Maxacalcitol

    103909-75-7

    Cutaneous

    Mebeverine Hydrochloride

    2753-45-9

    Oral

    Mebhydrolin napadisylate

    6153-33-9

    Oral

    Medium Chain Triglicerides

    73398-61-5

    Parenteral

    Medroxyprogesterone Acetate

    71-58-9

    Oral

    Mefenamic acid

    61-68-7

    Oral

    Meloxicam

    71125-38-7

    Oral;

    Parenteral;

    Cutaneous

    Melperone hydrochloride

    1622-79-3

    Oral;

    Inhalation

    Menthol

    1490-04-6

    Oral;

    Cutaneous;

    Inhalation

    Meropenem

    119478-56-7

    Oral;

    Parenteral

    Mesalazine

    89-57-6

    Oral;

    Metamizole methampyrone

    57904-20-8;

    68-89-3

    Oral;

    Parenteral;

    Rectal

    Metamizole sodium

    68-89-3

    Parenteral

    Metamizole sodium / Methampyrone

    68-89-3

    Oral;

    Parenteral

    Metformin HCl

    657-24-9

    Oral

    Metformin hydrochloride

    1115-70-4

    Oral

    Metformin Parenteral

    657-24-9

    Parenteral

    Methampyrone

    68-89-3

    Parenteral

    Methotrexate

    59-05-2;

    7413-34-5

    Parenteral

    Methyl Salicylate

    119-36-8

    Cutaneous

    Methyl Sulphonyl Methane

    67-71-0

    Oral

    Methylcobalamin

    13422-55-4

    Oral;

    Parenteral

    Methylergonovine

    113-42-8

    Oral;

    Parenteral

    Methylphenidate

    113-45-1

    Oral

    Methylprednisolone Sodium

    83-43-2;

    5015-36-1;

    2921-57-5;

    2375-03-3;

    86401-95-8

    Oral;

    Parenteral

    Metoclopramide HCl

    54143-57-6

    Oral;

    Parenteral

    Metoprolol

    51384-51-1

    Oral

    Metronidazole

    443-48-1

    Oral;

    Parenteral;

    Rectal;

    Cutaneous;

    Vaginal

    Miconazole

    22916-47-8

    Cutaneous;

    Vaginal

    Mirabegron

    223673-61-8

    Oral

    Misoprostol

    59122-46-2

    Oral

    Mometasone furoate

    105102-22-5

    Cutaneous

    Montelukast

    151767-02-1

    Oral

    Morphine

    57-27-2

    Oral

    Moxonidine

    75438-57-2

    Oral

    Mupirocin

    12650-69-0

    Oral;

    Cutaneous

    N-methylmorpholine

    109-02-4

    Parenteral

    Naldemedine

    916072-89-4

    Oral

    Nalfurafine hydrochloride

    152658-17-8

    Oral

    Naphazoline HCL

    550-99-2

    Ocular

    Nebivolol HCl

    152520-56-4

    Oral

    Neomycin Sulfate

    1405-10-3

    Oral;

    Cutaneous;

    Ocular

    Neostigmine Methylsulfate

    59-99-4

    Parenteral

    Netarsudil

    1254032-66-0

    Ocular

    Netilmicin

    56391-56-1

    Parenteral

    Nicardipine hydrochloride

    54527-84-3

    Parenteral

    Nicotinamide

    98-92-0

    Oral;

    Cutaneous

    Nifedipine micro

    21829-25-4

    Oral;

    Cutaneous

    Nimesulide

    51803-78-2

    Oral

    Nitrofurantoin

    67-20-9

    Oral

    Nitroglycerin 10%/lactose anhydrous

    55-63-0;

    63-42-3

    Oral

    Norethisteron

    68-22-4

    Oral

    Nystatin

    1400-61-9

    Oral;

    Parenteral;

    Cutaneous;

    Vaginal

    Olanzapine

    132539-06-1

    Oral

    Olmesartan medoxomil

    144689-63-4

    Oral

    Omega 3

    308081-97-2

    Oral

    Omeprazole

    73590-58-6

    Oral;

    Parenteral

    Omeprazole sodium

    73590-58-6

    Oral;

    Parenteral

    Ondansetron hydrochloride dihydrate

    103639-04-9

    Oral;

    Parenteral

    Opicapone

    923287-50-7

    Oral

    Ornidazole

    16773-42-5

    Oral

    Oxaceprol

    33996-33-7

    Oral

    Oxaliplatin

    61825-94-3

    Parenteral

    Oxycodone

    76-42-6

    Oral

    Oxymorphone

    76-41-5

    Oral

    Oxytetracyclin HCl

    2058-46-0

    Oral;

    Cutaneous

    Paclitaxel

    33069-62-4

    Parenteral

    Pantoprazole Sodium

    164579-32-2

    Oral;

    Parenteral

    Pantothenic acid

    79-83-4

    Oral;

    Cutaneous

    Paracetamol

    103-90-2

    Oral

    Paricalcitol

    131918-61-1

    Oral

    Paroxetine

    61869-08-7

    Oral

    Pectin

    18968-14-4

    Oral

    Permethrin

    52645-53-1

    Cutaneous

    Phenylephrine HCL

    61-76-7

    Oral;

    Parenteral

    Phenylpropanolamine HCL

    154-41-6

    Oral

    Phenytoin Sodium

    630-93-3

    Parenteral

    Phyllanthus niruri

    84775-91-7

    Oral

    Pidotimod

    121808-62-6

    Oral

    Pilocarpine Hydrochloride

    92-13-7

    Ocular

    Pioglitazone HCL

    112529-15-4

    Oral

    Piperacillin

    66258-76-2

    Parenteral

    Piperaquine phosphate

    4085-31-8

    Oral

    Piracetam

    7491-74-9

    Oral;

    Parenteral

    Piroxicam

    36322-90-4

    Oral;

    Parenteral

    Pitavastatin calcium

    1475511-69-1

    Oral

    Placenta

    n.a.

    Cutaneous

    Polymyxin B sulfate

    1405-20-5;

    1404-26-8

    Ocular

    Potassium Chloride

    7447-40-7

    Oral;

    Parenteral

    Potassium guaiacolsulfate_guaiacolsulfonate

    6100-07-8

    Oral

    Potassium iodide

    7681-11-0

    Oral

    Potassium Nitrate

    7757-79-1

    Oral;

    Cutaneous;

    Buccal

    Pramipexole dihydrochloride monohydrate

    191217-81-9

    Oral

    Pravastatin sodium

    81131-70-6

    Oral

    Prednisolone

    50-24-8

    Oral

    Prednisolone acetate

    52-21-1

    Ocular

    Pregabalin

    148553-50-8

    Oral

    Prilocaine

    721-50-6

    Parenteral;

    Cutaneous

    Progesterone

    57-83-0

    Vaginal

    Propofol

    2078-54-8

    Parenteral

    Pseudoephedrine HCL

    345-78-8

    Oral

    Purified egg lecithin

    8002-43-5;

    93685-90-6

    Parenteral

    Pyrazinamide

    98-96-4

    Oral;

    Inhalation

    Pyridoxine HCl

    58-56-0

    Oral;

    Parenteral

    Pyridoxine HCl / Vit. B6

    58-56-0

    Oral

    Quinfamide

    62265-68-3

    Oral

    Quinidine sulphate

    6591-63-5

    Oral

    Rabeprazole sodium

    117976-90-6

    Oral

    Ramipril

    87333-19-5

    Oral

    Ranitidine HCl

    66357-59-3

    Oral;

    Parenteral

    Rebamipide

    90098-04-7

    Oral

    Relugolix

    737789-87-6

    Oral

    Resmetirom

    920509-32-6

    Oral

    Riboflavin

    83-88-5

    Oral;

    Parenteral

    Riboflavin (sodium phosphate)

    130-40-5;

    83-88-5

    Parenteral

    Rifampicin

    13292-46-1

    Oral

    Rilpivirine

    500287-72-9

    Oral;

    Inhalation

    Rimegepant sulfate

    1374024-48-2

    Oral

    Ripasudil

    223645-67-8

    Ocular

    Risperidone

    106266-06-2

    Oral

    Rituximab

    174722-31-7

    Parenteral

    Rivaroxaban

    366789-02-8

    Oral

    Rosuvastatin

    287714-41-4

    Oral

    Rosuvastatin calcium

    287714-41-4

    Oral

    Roxadustat

    808118-40-3

    Oral

    Roxithromycin

    80214-83-1

    Oral

    Royal Jelly

    8031-67-2

    Oral

    Sacubitril

    149709-62-6

    Oral

    Sacubitril disodium

    149709-62-6

    Oral

    Sacubitril/Valsartan

    149709-62-6

    Oral

    Salicylic acid

    69-72-7

    Cutaneous

    Sauropus androgynus folium extract

    n.a.

    Oral

    Schizandrae Fructus Extract

    7432-28-2

    Oral

    Sertraline

    79617-96-2

    Oral

    Siberian pine needle oil

    8021-29-2

    Cutaneous;

    Inhalation

    Sildenafil citrate

    171599-83-0

    Oral

    Silymarin

    65666-07-1

    Oral

    Simethicone

    8050-81-5

    Oral

    Simvastatin

    79902-63-9

    Oral

    Sitafloxacin

    127254-12-0

    Oral

    Sodium acetate trihydrate

    127-09-3;

    6131-90-4

    Oral;

    Parenteral

    Sodium alendronate

    121268-17-5

    Oral

    Sodium Chloride

    7647-14-5

    Oral;

    Parenteral;

    Cutaneous

    Sodium citrate

    68-04-2

    Oral;

    Parenteral

    Sodium fluoride

    7681-49-4

    Cutaneous

    Sodium hypophosphite

    7681-53-0

    Oral;

    Parenteral

    Sodium Lactate

    72-17-3

    Parenteral

    Sodium pantothenate

    867-81-2

    Oral

    Sodium picosulfate

    10040-45-6

    Oral

    Sodium Selenite

    10102-18-8

    Oral

    Sodium Valproate

    99-66-1

    Oral;

    Parenteral

    Sorbitol

    50-70-4

    Parenteral;

    Rectal

    Soybean oil

    8001-22-7

    Cutaneous

    Sucralfate

    54182-58-0

    Oral

    Sugammadex sodium

    343306-79-6

    Parenteral

    Sulbactam

    68373-14-8

    Parenteral

    Sulbactan sodium

    94935-62-4

    Parenteral

    Sulfamethoxazole

    723-46-6

    Oral

    Sumatriptan succinate

    103628-48-4

    Oral

    Suvorexant

    1030377-33-3

    Oral

    Tadalafil

    171596-29-5

    Oral

    Tafluprost

    209860-87-7

    Ocular

    Tamsulosin

    106133-20-4

    Oral

    Taurine

    107-35-7

    Oral

    Tazobactam

    89786-04-9

    Parenteral

    Telmisartan

    144701-48-4

    Oral

    Teneligliptin HBr

    906093-29-6

    Oral

    Terazosine hydrochloride

    63074-08-8

    Oral

    Terbutaline sulphate

    23031-32-5

    Oral

    Terephthalic acid

    100-21-0

    Parenteral

    Testosterone

    58-22-0

    TransCutaneous

    Testosterone undecanoate

    5949-44-0

    Parenteral

    Tetracaine hydrochloride

    136-47-0

    Rectal

    Tetracycline

    64-75-5

    Oral

    Tetrahydrozoline HCL

    522-48-5;

    84-22-0

    Ocular

    Theophyllin

    58-55-9

    Oral

    Thiamine hydrochloride

    67-03-8

    Oral

    Thiamine mononitrate

    532-43-4

    Oral;

    Parenteral

    Thiamphenicol

    15318-45-3

    Oral

    Thiamphenicol

    2611-61-2

    Oral

    Thiamphenicol glycinate hydrochloride

    2611-61-2

    Oral

    Thymol

    89-83-8

    Cutaneous;

    Inhalation

    Tibolone

    5630-53-5

    Oral

    Ticagrelor

    274693-27-5

    Oral

    Timolol maleate

    26921-17-5

    Ocular

    Tobramycin

    32986-56-4

    Ocular

    Topiramate

    97240-79-4

    Oral

    Torasemide

    56211-40-6

    Oral

    Tramadol HCl

    27203-92-5

    Oral

    Tramadol HCl

    36282-47-0

    Parenteral

    Tranexamic acid

    1197-18-8

    Oral;

    Parenteral

    Travoprost

    157283-68-6

    Ocular

    Treprostinil Sodium

    289480-64-4

    Parenteral;

    Inhalation

    Triamcinolone

    124-94-7

    Oral;

    Cutaneous

    Triamcinolone acetonide

    76-25-5

    Cutaneous

    Trimethoprim

    738-70-5

    Oral

    Triprolidin HCL

    550-70-9;

    6138-79-0

    Oral

    Tropicamide

    1508-75-4

    Ocular

    Turpentine oil

    8006-64-2

    Cutaneous;

    Inhalation

    Unoprostone

    120373-36-6

    Ocular

    Upadacitinib

    1310726-60-3

    Oral

    Valacyclovir HCl

    124832-26-4

    Oral

    Valproate bismuth

    60364-28-5

    Oral;

    Inhalation

    Valproic acid

    99-66-1

    Oral;

    Parenteral

    Vamorolone

    13209-41-1

    Oral

    Vancomycin

    1404-90-6

    Parenteral

    Venlafaxine

    93413-69-5

    Oral

    Venlafaxine Hydrochloride

    99300-78-4

    Oral

    Vericiguat

    1350653-20-1

    Oral

    Vibegron

    1190389-15-1

    Oral

    Vildagliptin

    274901-16-5

    Oral

    Vincristine

    2068-78-2

    Parenteral

    Vinpocetine

    42971-09-5

    Oral

    Vitamin A

    68-26-8;

    79-81-2;

    127-47-9

    Oral

    Vitamin C

    50-81-7;

    134-03-2

    Oral

    Vitamin D3 (Cholecalciferol)

    67-97-0

    Oral

    Vitamin E

    52225-20-4;

    7695-91-2;

    1406-18-4;

    59-02-9

    Oral

    Vonoprazan fumarate

    1260141-27-2; 881681-00-1

    Oral

    Voriconazole

    137234-62-9

    Oral

    Warfarin sodium

    129-06-6

    Oral;

    Inhalation

    Xylitol

    87-99-0

    Oral;

    Parenteral

    Zinc (II) Chloride

    7646-85-7

    Parenteral

    Zinc oxide

    1314-13-2

    Cutaneous

    Zinc picolinate

    17949-65-4

    Oral

    Zinc sulphate

    7733-02-0

    Oral;

    Cutaneous

    Zoledronic acid

    118072-93-8

    Parenteral

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